Case-03 : Marketing

Introducing Past Case Studies Utilizing Data from MDV Database.

Case Sample (Marketing)

Switch Rates, Time-to-switch, and Switch Atterns of Antiretroviral Therapy in People Living with Human Immunodeficiency Virus in Japan, in a Hospital-claim Database

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Ruzicka DJ, Kuroishi N, Oshima N, et al. Switch rates, time-to-switch, and switch patterns of antiretroviral therapy in people living with human immunodeficiency virus in Japan, in a hospital-claim database. BMC Infect Dis. 2019;19(1):505. Published 2019 Jun 10. doi:10.1186/s12879-019-4129-6

Introduction

  • Antiretroviral therapy (ART) increased HIV patient’s life expectance
  • Combination of the following medications have been the recommended regimen in Japanese guidelines
    • Backbone (2 nucleoside reverse transcriptase inhibitors )
    • Add on of an anchor drug
      • a.integrase strand transfer inhibitors (INSTI)
      • b.non-nucleoside reverse transcriptase inhibitors (NNRTI)
      • c.protease inhibitors (PI)

Objective of Study

To understand the switch rates and time-to-switch of ART regimens of people with HIV between 2008 to 2016 in Japan

Study Design and Criteria

Study Design: Retrospective Observational Database Study.

Target Period: April 2008 – December 2016

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Definition of Regimen Switch

Regimen switch is referring to only on anchor drug classes.
Change in anchor drug classes within 28 days of a different anchor drug is considered a change in regimen.

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Patient Disposition

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Patient Background Information

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Switching Pattern and Timing

Switching patterns of anchor drug class in ART regimens by switching timing from 2011 to 2016

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Time-to-switch

Time-to-switch of ART regimens according to anchor drug class from 2011 to 2016

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Conclusion

  • ART regimen including INSTI maintained low switch rate for long durations
  • Major switch was seen mainly from NNRTI or PI to INSTI for secondary treatment suggesting INSTI is much tentative drug for HIV patients

Service Utilized for Case Study:

Abbreviation in Article

  • 3TCLamivudine
  • ABCAbacavir
  • AEAdverse event
  • ARTAntiretroviral therapy
  • ATV/rAtazanavir/ritonavir
  • AZTZidovudine
  • CIConfidence interval
  • DTGDolutegravir
  • EFVEfavirenz
  • EIEntry inhibitor
  • FTCEmtricitabine
  • HIVHuman immunodeficiency virus
  • HRHazard ratio
  • ICD-10The International Statistical Classification of Diseases and Related Health Problems 10th Revision
  • INSTIIntegrase strand transfer inhibitor
  • NNRTINon-nucleoside reverse transcriptase inhibitor
  • NRTINucleoside reverse transcriptase inhibitor
  • PIProtease inhibitor
  • PLWHPeople living with human immunodeficiency virus
  • TAFTenofovir alafenamide fumarate
  • TDFTenofovir disoproxil fumarate

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