Introducing Past Case Studies using Data from MDV Database.

Case Study (Marketing)

Switch Rates, Time-to-switch, and Switch Patterns of Antiretroviral Therapy in People Living with Human Immunodeficiency Virus in Japan, using a Hospital-claim Database

Ruzicka DJ, Kuroishi N, Oshima N, et al. Switch rates, time-to-switch, and switch patterns of antiretroviral therapy in people living with human immunodeficiency virus in Japan, in a hospital-claim database. BMC Infect Dis. 2019;19(1):505. Published 2019 Jun 10. doi:10.1186/s12879-019-4129-6

Introduction

• Antiretroviral therapy (ART)
  contributes to extend HIV patient’s life expectancy
• Combination of the following medications have been
  the recommended regimen in Japanese guidelines:

• Backbone therapy: 2 nucleoside reverse transcriptase inhibitors
• Add on of an anchor drug among:

• Integrase strand transfer inhibitors (INSTIs)
• Non-nucleoside reverse transcriptase inhibitors (NNRTIs)
• Protease inhibitors (PIs)
• Entry inhibitors (Els)

Objectives of Study

To understand the switch rates and time-to-switch of ART regimens in patients with HIV between 2008 to 2016 in Japan

Study Design and Criteria

Study Design: Retrospective Observational Database Study.

Target Period: April 2008 – December 2016

Definition of Regimen Switch

Regimen switch is referring to only when adopting anchor drug classes.

Change in anchor drug classes within 28 days of a different anchor drug is considered a change in regimen.

Patient Disposition

Distributions of anchor drug class and backbone in the ART regimens by year

Switching Patterns and Timing

Switching patterns of anchor drug class in ART regimens by switching timing from 2011 to 2016

Time-to-switch

Time-to-switch of ART regimens according to anchor drug class from 2011 to 2016

Service used for the Case Study:

Abbreviation in Article