Case-02: Health Economic Outcome Research (HEOR)

Introducing past case studies using data from MDV Database.

Case Study (Health Economics Outcome Research)

Retrospective Analysis of Medical Costs and Resource Utilization for Severe Hypoglycemic Events in Patients with Type 2 Diabetes in Japan

Ikeda, Y., Kubo, T., Oda, E., Abe, M., & Tokita, S. (2019). Retrospective analysis of medical costs and resource utilization for severe hypoglycemic events in patients with type 2 diabetes in Japan. Journal of diabetes investigation, 10(3), 857-865.


  • Within treatment of type 2 diabetes mellitus (T2DM), patients’ onset with hypoglycemia is observed and severe hypoglycemia events (SHE) require hospital treatment.
  • Economic burden analysis was conducted in Japan providing information on medical cost per SHE and overall medical cost for SHE but actual medical resource utilization after SHE has not been confirmed.
  • This analysis is a follow-up analysis based on the prior retrospective study confirming the incidence rate and factors associated with severe hypoglycemia in patients with T2DM.

Objectives of Study

To underline the actual medical costs and hospitals stay or visits due to SHEs in Japan

Study Design and Criteria

Study Design: Retrospective Observational Study

Target Period: April 2008 - September 2014

Definition of Severe Hypoglycemic Episodes

Severe Hypoglycemic Episode broken down into the following categories:

Patient Characteristics of the Study Population

Flow Chart Showing Patient Composition for Cost Analysis

Medical Costs Per Severe Hypoglycemic Event

Composition of the Medical Costs


  • Direct costs of SHEs were high in Japan
  • Most medical resources were required for the following.
  1. Diagnosis and testing
  2. Treatment of related symptoms and after-effects
  3. Treatment for SHEs
  • T2DM patients are prone to hypoglycemia as the patient ages
  • To implement more personal management under guidelines in order to reduce hypoglycemia
    ⇒Ultimately decrease the economic burden of diabetic patients

Service used for the Case Study:

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About Japanese Healthcare System

What you need to know about the healthcare system in Japan before using the data.


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